There are
341 mi
from Fayetteville, AR to Festus, MO
That's the driving distance. It would take 6 hours 47 mins to go from Fayetteville, Arkansas to Festus, Missouri.
The flight distance (direct flight from Fayetteville, AR to Festus, MO) is 255.21 mi.
341 mi = 549.43 kms