There are
367 mi
from Fayetteville, AR to Edwardsville, IL
That's the driving distance. It would take 7 hours 11 mins to go from Fayetteville, Arkansas to Edwardsville, Illinois.
The flight distance (direct flight from Fayetteville, AR to Edwardsville, IL) is 298.72 mi.
367 mi = 589.89 kms