There are
329 mi
from Fayetteville, AR to Clarksdale, MS
That's the driving distance. It would take 6 hours 8 mins to go from Fayetteville, Arkansas to Clarksdale, Mississippi.
The flight distance (direct flight from Fayetteville, AR to Clarksdale, MS) is 240.04 mi.
329 mi = 528.86 kms