There are
360 mi
from Fayetteville, AR to Cape Girardeau, MO
That's the driving distance. It would take 7 hours 18 mins to go from Fayetteville, Arkansas to Cape Girardeau, Missouri.
The flight distance (direct flight from Fayetteville, AR to Cape Girardeau, MO) is 270.99 mi.
360 mi = 580.05 kms