There are
348 mi
from Fayetteville, AR to Cahokia, IL
That's the driving distance. It would take 6 hours 45 mins to go from Fayetteville, Arkansas to Cahokia, Illinois.
The flight distance (direct flight from Fayetteville, AR to Cahokia, IL) is 278.45 mi.
348 mi = 560.57 kms