There are
281 mi
from Evansville, IN to Hannibal, MO
That's the driving distance. It would take 5 hours 33 mins to go from Evansville, Indiana to Hannibal, Missouri.
The flight distance (direct flight from Evansville, IN to Hannibal, MO) is 236.50 mi.
281 mi = 452.76 kms