There are
141 mi
from Evansville, IN to Cape Girardeau, MO
That's the driving distance. It would take 2 hours 54 mins to go from Evansville, Indiana to Cape Girardeau, Missouri.
The flight distance (direct flight from Evansville, IN to Cape Girardeau, MO) is 116.03 mi.
141 mi = 226.51 kms