There are
1,855 mi
from Escondido, CA to Sikeston, MO
That's the driving distance. It would take 1 day 8 hours to go from Escondido, California to Sikeston, Missouri.
The flight distance (direct flight from Escondido, CA to Sikeston, MO) is 1,572.28 mi.
1,855 mi = 2,985.50 kms