There are
381 mi
from Escondido, CA to Mesquite, NV
That's the driving distance. It would take 6 hours 52 mins to go from Escondido, California to Mesquite, Nevada.
The flight distance (direct flight from Escondido, CA to Mesquite, NV) is 306.70 mi.
381 mi = 612.95 kms