There are
545 mi
from Edmond, OK to Cape Girardeau, MO
That's the driving distance. It would take 10 hours 7 mins to go from Edmond, Oklahoma to Cape Girardeau, Missouri.
The flight distance (direct flight from Edmond, OK to Cape Girardeau, MO) is 456.57 mi.
545 mi = 877.61 kms