Miles between Durham, NC and Knoxville, TN

There are
343 mi
from Durham, NC to Knoxville, TN

That's the driving distance. It would take 6 hours 27 mins to go from Durham, North Carolina to Knoxville, Tennessee.

The flight distance (direct flight from Durham, NC to Knoxville, TN) is 280.78 mi.

343 mi = 552.60 kms