There are
1,605 mi
from Duluth, MN to Sanford, FL
That's the driving distance. It would take 1 day 6 hours to go from Duluth, Minnesota to Sanford, Florida.
The flight distance (direct flight from Duluth, MN to Sanford, FL) is 1,375.27 mi.
1,605 mi = 2,583.18 kms