There are
1,848 mi
from Downey, CA to Sikeston, MO
That's the driving distance. It would take 1 day 8 hours to go from Downey, California to Sikeston, Missouri.
The flight distance (direct flight from Downey, CA to Sikeston, MO) is 1,614.18 mi.
1,848 mi = 1.61 kms