There are
1,882 mi
from Downey, CA to Cape Girardeau, MO
That's the driving distance. It would take 1 day 9 hours to go from Downey, California to Cape Girardeau, Missouri.
The flight distance (direct flight from Downey, CA to Cape Girardeau, MO) is 1,617.57 mi.
1,882 mi = 1.61 kms