There are
389 mi
from Des Plaines, IL to Paducah, KY
That's the driving distance. It would take 7 hours 14 mins to go from Des Plaines, Illinois to Paducah, Kentucky.
The flight distance (direct flight from Des Plaines, IL to Paducah, KY) is 344.13 mi.
389 mi = 625.65 kms