Miles between Des Moines, IA and St Louis, MO

There are
348 mi
from Des Moines, IA to St Louis, MO

That's the driving distance. It would take 6 hours 57 mins to go from Des Moines, Iowa to St Louis, Missouri.

The flight distance (direct flight from Des Moines, IA to St Louis, MO) is 273.21 mi.

348 mi = 559.55 kms