There are
536 mi
from Des Moines, IA to Seymour, IN
That's the driving distance. It would take 9 hours 49 mins to go from Des Moines, Iowa to Seymour, Indiana.
The flight distance (direct flight from Des Moines, IA to Seymour, IN) is 445.70 mi.
536 mi = 862.57 kms