There are
991 mi
from Des Moines, IA to Seguin, TX
That's the driving distance. It would take 17 hours 7 mins to go from Des Moines, Iowa to Seguin, Texas.
The flight distance (direct flight from Des Moines, IA to Seguin, TX) is 866.26 mi.
991 mi = 1,594.41 kms