There are
523 mi
from Des Moines, IA to Paducah, KY
That's the driving distance. It would take 10 hours 10 mins to go from Des Moines, Iowa to Paducah, Kentucky.
The flight distance (direct flight from Des Moines, IA to Paducah, KY) is 411 mi.
523 mi = 840.91 kms