There are
352 mi
from Des Moines, IA to Lexington, NE
That's the driving distance. It would take 6 hours 14 mins to go from Des Moines, Iowa to Lexington, Nebraska.
The flight distance (direct flight from Des Moines, IA to Lexington, NE) is 323.81 mi.
352 mi = 566.46 kms