There are
1,006 mi
from Des Moines, IA to Lexington, NC
That's the driving distance. It would take 19 hours 5 mins to go from Des Moines, Iowa to Lexington, North Carolina.
The flight distance (direct flight from Des Moines, IA to Lexington, NC) is 821.92 mi.
1,006 mi = 1.61 kms