There are
182 mi
from Des Moines, IA to Keokuk, IA
That's the driving distance. It would take 3 hours 41 mins to go from Des Moines, Iowa to Keokuk, Iowa.
The flight distance (direct flight from Des Moines, IA to Keokuk, IA) is 142.08 mi.
182 mi = 292.11 kms