Miles between Des Moines, IA and Guymon, OK

There are
641 mi
from Des Moines, IA to Guymon, OK

That's the driving distance. It would take 11 hours 52 mins to go from Des Moines, Iowa to Guymon, Oklahoma.

The flight distance (direct flight from Des Moines, IA to Guymon, OK) is 541.30 mi.

641 mi = 1,032.12 kms