There are
369 mi
from Des Moines, IA to Edwardsville, IL
That's the driving distance. It would take 7 hours 14 mins to go from Des Moines, Iowa to Edwardsville, Illinois.
The flight distance (direct flight from Des Moines, IA to Edwardsville, IL) is 272.63 mi.
369 mi = 594.12 kms