Miles between Des Moines, IA and Clayton, MO

There are
341 mi
from Des Moines, IA to Clayton, MO

That's the driving distance. It would take 6 hours 50 mins to go from Des Moines, Iowa to Clayton, Missouri.

The flight distance (direct flight from Des Moines, IA to Clayton, MO) is 268.09 mi.

341 mi = 549.59 kms