Miles between Des Moines, IA and Cape Girardeau, MO

There are
449 mi
from Des Moines, IA to Cape Girardeau, MO

That's the driving distance. It would take 8 hours 48 mins to go from Des Moines, Iowa to Cape Girardeau, Missouri.

The flight distance (direct flight from Des Moines, IA to Cape Girardeau, MO) is 368.25 mi.

449 mi = 721.90 kms