There are
622 mi
from Denton, TX to Cape Girardeau, MO
That's the driving distance. It would take 11 hours 3 mins to go from Denton, Texas to Cape Girardeau, Missouri.
The flight distance (direct flight from Denton, TX to Cape Girardeau, MO) is 513.99 mi.
622 mi = 1,001.22 kms