There are
881 mi
from Daytona Beach, FL to Sikeston, MO
That's the driving distance. It would take 16 hours 26 mins to go from Daytona Beach, Florida to Sikeston, Missouri.
The flight distance (direct flight from Daytona Beach, FL to Sikeston, MO) is 725.02 mi.
881 mi = 1,417.97 kms