There are
415 mi
from Dayton, OH to Cape Girardeau, MO
That's the driving distance. It would take 7 hours 54 mins to go from Dayton, Ohio to Cape Girardeau, Missouri.
The flight distance (direct flight from Dayton, OH to Cape Girardeau, MO) is 333.99 mi.
415 mi = 668.65 kms