There are
412 mi
from Davenport, IA to Sikeston, MO
That's the driving distance. It would take 7 hours 37 mins to go from Davenport, Iowa to Sikeston, Missouri.
The flight distance (direct flight from Davenport, IA to Sikeston, MO) is 325.41 mi.
412 mi = 662.47 kms