Miles between Columbus, OH and Greenville, SC

There are
453 mi
from Columbus, OH to Greenville, SC

That's the driving distance. It would take 9 hours 15 mins to go from Columbus, Ohio to Greenville, South Carolina.

The flight distance (direct flight from Columbus, OH to Greenville, SC) is 354.52 mi.

453 mi = 728.40 kms