Miles between Columbia, SC and Sikeston, MO

There are
640 mi
from Columbia, SC to Sikeston, MO

That's the driving distance. It would take 12 hours 7 mins to go from Columbia, South Carolina to Sikeston, Missouri.

The flight distance (direct flight from Columbia, SC to Sikeston, MO) is 520.62 mi.

640 mi = 1,029.32 kms