There are
2,726 mi
from Columbia, SC to Klamath Falls, OR
That's the driving distance. It would take 2 days 2 hours to go from Columbia, South Carolina to Klamath Falls, Oregon.
The flight distance (direct flight from Columbia, SC to Klamath Falls, OR) is 2,263.80 mi.
2,726 mi = 3.22 kms