Miles between Columbia, SC and Key Biscayne, FL

There are
643 mi
from Columbia, SC to Key Biscayne, FL

That's the driving distance. It would take 11 hours 53 mins to go from Columbia, South Carolina to Key Biscayne, Florida.

The flight distance (direct flight from Columbia, SC to Key Biscayne, FL) is 576.32 mi.

643 mi = 1,034.66 kms