Miles between Columbia, SC and Cape Girardeau, MO

There are
645 mi
from Columbia, SC to Cape Girardeau, MO

That's the driving distance. It would take 12 hours 26 mins to go from Columbia, South Carolina to Cape Girardeau, Missouri.

The flight distance (direct flight from Columbia, SC to Cape Girardeau, MO) is 527.91 mi.

645 mi = 1,038.67 kms