There are
1,110 mi
from Columbia, MO to Zephyrhills, FL
That's the driving distance. It would take 20 hours 39 mins to go from Columbia, Missouri to Zephyrhills, Florida.
The flight distance (direct flight from Columbia, MO to Zephyrhills, FL) is 941.95 mi.
1,110 mi = 1.61 kms