There are
1,117 mi
from Columbia, MO to Poughkeepsie, NY
That's the driving distance. It would take 21 hours 8 mins to go from Columbia, Missouri to Poughkeepsie, New York.
The flight distance (direct flight from Columbia, MO to Poughkeepsie, NY) is 986.31 mi.
1,117 mi = 1.61 kms