There are
1,394 mi
from Columbia, MO to Mesquite, NV
That's the driving distance. It would take 23 hours 57 mins to go from Columbia, Missouri to Mesquite, Nevada.
The flight distance (direct flight from Columbia, MO to Mesquite, NV) is 1,191.60 mi.
1,394 mi = 1.61 kms