There are
1,949 mi
from Columbia, MO to Issaquah, WA
That's the driving distance. It would take 1 day 9 hours to go from Columbia, Missouri to Issaquah, Washington.
The flight distance (direct flight from Columbia, MO to Issaquah, WA) is 1,595.89 mi.
1,949 mi = 1.61 kms