Miles between Columbia, MO and Cape Girardeau, MO

There are
225 mi
from Columbia, MO to Cape Girardeau, MO

That's the driving distance. It would take 4 hours 23 mins to go from Columbia, Missouri to Cape Girardeau, Missouri.

The flight distance (direct flight from Columbia, MO to Cape Girardeau, MO) is 190.65 mi.

225 mi = 362.78 kms