There are
1,735 mi
from Clayton, MO to Calexico, CA
That's the driving distance. It would take 1 day 6 hours to go from Clayton, Missouri to Calexico, California.
The flight distance (direct flight from Clayton, MO to Calexico, CA) is 1,466.79 mi.
1,735 mi = 2,792.03 kms