There are
320 mi
from Clarksville, TN to Waynesville, NC
That's the driving distance. It would take 6 hours 6 mins to go from Clarksville, Tennessee to Waynesville, North Carolina.
The flight distance (direct flight from Clarksville, TN to Waynesville, NC) is 254.63 mi.
320 mi = 514.57 kms