There are
157 mi
from Clarksville, TN to Sikeston, MO
That's the driving distance. It would take 3 hours 10 mins to go from Clarksville, Tennessee to Sikeston, Missouri.
The flight distance (direct flight from Clarksville, TN to Sikeston, MO) is 125.74 mi.
157 mi = 253.31 kms