There are
443 mi
from Clarksville, TN to Keokuk, IA
That's the driving distance. It would take 8 hours 38 mins to go from Clarksville, Tennessee to Keokuk, Iowa.
The flight distance (direct flight from Clarksville, TN to Keokuk, IA) is 345.23 mi.
443 mi = 713.29 kms