There are
163 mi
from Clarksville, TN to Cape Girardeau, MO
That's the driving distance. It would take 3 hours 29 mins to go from Clarksville, Tennessee to Cape Girardeau, Missouri.
The flight distance (direct flight from Clarksville, TN to Cape Girardeau, MO) is 130.74 mi.
163 mi = 262.64 kms