There are
342 mi
from Clarksville, TN to Ashland, KY
That's the driving distance. It would take 6 hours 35 mins to go from Clarksville, Tennessee to Ashland, Kentucky.
The flight distance (direct flight from Clarksville, TN to Ashland, KY) is 291.67 mi.
342 mi = 550.41 kms