There are
367 mi
from Cicero, IL to Cape Girardeau, MO
That's the driving distance. It would take 6 hours 56 mins to go from Cicero, Illinois to Cape Girardeau, Missouri.
The flight distance (direct flight from Cicero, IL to Cape Girardeau, MO) is 327.41 mi.
367 mi = 591.21 kms