There are
2,104 mi
from Chico, CA to Cape Girardeau, MO
That's the driving distance. It would take 1 day 12 hours to go from Chico, California to Cape Girardeau, Missouri.
The flight distance (direct flight from Chico, CA to Cape Girardeau, MO) is 1,745.67 mi.
2,104 mi = 3.22 kms