There are
1,020 mi
from Cheyenne, WY to Sikeston, MO
That's the driving distance. It would take 18 hours 11 mins to go from Cheyenne, Wyoming to Sikeston, Missouri.
The flight distance (direct flight from Cheyenne, WY to Sikeston, MO) is 867.80 mi.
1,020 mi = 1,642.07 kms