There are
1,244 mi
from Cheyenne, WY to Lompoc, CA
That's the driving distance. It would take 21 hours 49 mins to go from Cheyenne, Wyoming to Lompoc, California.
The flight distance (direct flight from Cheyenne, WY to Lompoc, CA) is 961.75 mi.
1,244 mi = 2,001.39 kms